Publications

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus.

Marzo A, Galli S, Lopes D, McLeod F, Podpolny M, Segovia-Roldan M, Ciani L, Purro S, Cacucci F, Gibb A, Salinas PC
Curr Biol. 2016 Aug 31. pii: S0960-9822(16)30775-8. doi: 10.1016/j.cub.2016.07.024. [Epub ahead of print]
PMID: 27593374

Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.

Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes DM, Anane D, McLeod F, Rosso SB, Gibb A, Salinas PC
Nat Commun. 2015 Sep 24;6:8302. doi: 10.1038/ncomms9302.
PMID: 26400647

Wnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8.

Stamatakou E, Hoyos-Flight M, Salinas PC
PLoS One. 2015 Aug 7;10(8):e0134976. doi: 10.1371/journal.pone.0134976. eCollection 2015.
PMID: 26252776

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice.

Galli S, Lopes DM, Ammari R, Kopra J, Millar SE, Gibb A, Salinas PC
Nat Commun. 2014 Oct 16;5:4992. doi: 10.1038/ncomms5992.
PMID: 25318560

Postsynaptic assembly: a role for Wnt signaling.

Stamatakou E, Salinas PC
Dev Neurobiol. 2014 Aug;74(8):818-27. doi: 10.1002/dneu.22138. Epub 2013 Nov 15. Review.
PMID: 24105999

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases.

Purro SA, Galli S, Salinas PC
J Mol Cell Biol. 2014 Feb;6(1):75-80. doi: 10.1093/jmcb/mjt049. Epub 2014 Jan 20. Review.
PMID: 24449494

Wnts in action: from synapse formation to synaptic maintenance.

Dickins EM, Salinas PC
Front Cell Neurosci. 2013 Nov 5;7:162. doi: 10.3389/fncel.2013.00162. Review.
PMID: 24223536

Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation.

Hiester BG, Galati DF, Salinas PC, Jones KR
Mol Cell Neurosci. 2013 Sep;56:115-27. doi: 10.1016/j.mcn.2013.04.006. Epub 2013 Apr 30.
PMID: 23639831

Activity-dependent spine morphogenesis: a role for the actin-capping protein Eps8.

Stamatakou E, Marzo A, Gibb A, Salinas PC
J Neurosci. 2013 Feb 6;33(6):2661-70. doi: 10.1523/JNEUROSCI.0998-12.2013.
PMID: 23392693

Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts.

Nethe M, de Kreuk BJ, Tauriello DV, Anthony EC, Snoek B, Stumpel T, Salinas PC, Maurice MM, Geerts D, Deelder AM, Hensbergen PJ, Hordijk PL
J Cell Sci. 2012 Jul 15;125(Pt 14):3430-42. doi: 10.1242/jcs.100925. Epub 2012 Mar 30.
PMID: 22467858

The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss.

Purro SA, Dickins EM, Salinas PC
J Neurosci. 2012 Mar 7;32(10):3492-8. doi: 10.1523/JNEUROSCI.4562-11.2012.
PMID: 22399772

Wnt signaling in the vertebrate central nervous system: from axon guidance to synaptic function.

Salinas PC
Cold Spring Harb Perspect Biol. 2012 Feb 1;4(2). pii: a008003. doi: 10.1101/cshperspect.a008003. Review.
PMID: 22300976

Dual roles for Wnt signalling during the formation of the vertebrate neuromuscular junction.

Henríquez JP, Salinas PC
Acta Physiol (Oxf). 2012 Jan;204(1):128-36. doi: 10.1111/j.1748-1716.2011.02295.x. Epub 2011 May 7. Review.
PMID: 21554559

Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II.

Ciani L, Boyle KA, Dickins E, Sahores M, Anane D, Lopes DM, Gibb AJ, Salinas PC
Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10732-7. doi: 10.1073/pnas.1018132108. Epub 2011 Jun 13.
PMID: 21670302

Wnt signaling during synaptic development and plasticity.

Budnik V, Salinas PC
Curr Opin Neurobiol. 2011 Feb;21(1):151-9. doi: 10.1016/j.conb.2010.12.002. Epub 2011 Jan 14. Review.
PMID: 21239163

Activity-mediated synapse formation a role for Wnt-Fz signaling.

Sahores M, Salinas PC
Curr Top Dev Biol. 2011;97:119-36. doi: 10.1016/B978-0-12-385975-4.00011-5.
PMID: 22074604

Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis.

Sahores M, Gibb A, Salinas PC
Development. 2010 Jul;137(13):2215-25. doi: 10.1242/dev.046722.
PMID: 20530549

Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin.

Henriquez JP, Webb A, Bence M, Bildsoe H, Sahores M, Hughes SM, Salinas PC
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18812-7. doi: 10.1073/pnas.0806300105. Epub 2008 Nov 19.
PMID: 19020093

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli.

Purro SA, Ciani L, Hoyos-Flight M, Stamatakou E, Siomou E, Salinas PC
J Neurosci. 2008 Aug 20;28(34):8644-54. doi: 10.1523/JNEUROSCI.2320-08.2008.
PMID: 18716223

From neuronal activity to the actin cytoskeleton: a role for CaMKKs and betaPIX in spine morphogenesis.

Ciani L, Salinas PC
Neuron. 2008 Jan 10;57(1):3-4. doi: 10.1016/j.neuron.2007.12.017.
PMID: 18184558

Wnt signaling in neural circuit assembly.

Salinas PC, Zou Y
Annu Rev Neurosci. 2008;31:339-58. doi: 10.1146/annurev.neuro.31.060407.125649. Review.
PMID: 18558859

c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability.

Ciani L, Salinas PC
BMC Cell Biol. 2007 Jul 3;8:27.
PMID: 17608927

Modulation of the microtubule cytoskeleton: a role for a divergent canonical Wnt pathway.

Salinas PC
Trends Cell Biol. 2007 Jul;17(7):333-42. Epub 2007 Jul 20. Review.
PMID: 17643305

Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release.

Ahmad-Annuar A, Ciani L, Simeonidis I, Herreros J, Fredj NB, Rosso SB, Hall A, Brickley S, Salinas PC
J Cell Biol. 2006 Jul 3;174(1):127-39.
PMID: 16818724

Retrograde signalling at the synapse: a role for Wnt proteins.

Salinas PC
Biochem Soc Trans. 2005 Dec;33(Pt 6):1295-8. Review.
PMID: 16246102

Wnt signaling in neural circuit development.

Fradkin LG, Garriga G, Salinas PC, Thomas JB, Yu X, Zou Y
J Neurosci. 2005 Nov 9;25(45):10376-8. Review. No abstract available.
PMID: 16280576

Signaling at the vertebrate synapse: new roles for embryonic morphogens?

Salinas PC
J Neurobiol. 2005 Sep 15;64(4):435-45. Review.
PMID: 16041761

WNTs in the vertebrate nervous system: from patterning to neuronal connectivity.

Ciani L, Salinas PC
Nat Rev Neurosci. 2005 May;6(5):351-62. Review. Erratum in: Nat Rev Neurosci. 2005 Jul;6(7):582.
PMID: 15832199

Cadherins and catenins in synapse development.

Salinas PC, Price SR
Curr Opin Neurobiol. 2005 Feb;15(1):73-80. Review.
PMID: 15721747

Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development.

Rosso SB, Sussman D, Wynshaw-Boris A, Salinas PC
Nat Neurosci. 2005 Jan;8(1):34-42. Epub 2004 Dec 19.
PMID: 15608632

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules.

Ciani L, Krylova O, Smalley MJ, Dale TC, Salinas PC
J Cell Biol. 2004 Jan 19;164(2):243-53.
PMID: 14734535

The morphogen sonic hedgehog collaborates with netrin-1 to guide axons in the spinal cord.

Salinas PC
Trends Neurosci. 2003 Dec;26(12):641-3. Review.
PMID: 14624844

Neurobiology: backchat at the synapse.

Salinas PC
Nature. 2003 Oct 2;425(6957):464-7. No abstract available.
PMID: 14523428

Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea.

Dabdoub A, Donohue MJ, Brennan A, Wolf V, Montcouquiol M, Sassoon DA, Hseih JC, Rubin JS, Salinas PC, Kelley MW
Development. 2003 Jun;130(11):2375-84.
PMID: 12702652

Synaptogenesis: Wnt and TGF-beta take centre stage.

Salinas PC
Curr Biol. 2003 Jan 21;13(2):R60-2.
PMID: 12546806

WNT-3, expressed by motoneurons, regulates terminal arborization of neurotrophin-3-responsive spinal sensory neurons.

Krylova O, Herreros J, Cleverley KE, Ehler E, Henriquez JP, Hughes SM, Salinas PC
Neuron. 2002 Sep 12;35(6):1043-56.
PMID: 12354395

Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons.

Hall AC, Brennan A, Goold RG, Cleverley K, Lucas FR, Gordon-Weeks PR, Salinas PC
Mol Cell Neurosci. 2002 Jun;20(2):257-70.
PMID: 12093158

Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3beta.

Krylova O, Messenger MJ, Salinas PC
J Cell Biol. 2000 Oct 2;151(1):83-94.
PMID: 11018055

Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling.

Hall AC, Lucas FR, Salinas PC
Cell. 2000 Mar 3;100(5):525-35.
PMID: 10721990

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.

Meijer L, Thunnissen AM, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR
Chem Biol. 2000 Jan;7(1):51-63.
PMID: 10662688

Lithium and synaptic plasticity.

Salinas PC, Hall AC
Bipolar Disord. 1999 Dec;1(2):87-90. Review.
PMID: 11252664

WNT signaling in the control of hair growth and structure.

Millar SE, Willert K, Salinas PC, Roelink H, Nusse R, Sussman DJ, Barsh GS
Dev Biol. 1999 Mar 1;207(1):133-49.
PMID: 10049570

Control of muscle fibre and motoneuron diversification.

Hughes SM, Salinas PC
Curr Opin Neurobiol. 1999 Feb;9(1):54-64. Review.
PMID: 10072365

Wnt factors in axonal remodelling and synaptogenesis.

Salinas PC
Biochem Soc Symp. 1999;65:101-9. Review.
PMID: 10320935

Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium.

Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC
J Cell Sci. 1998 May;111 ( Pt 10):1351-61.
PMID: 9570753

WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons.

Lucas FR, Salinas PC
Dev Biol. 1997 Dec 1;192(1):31-44.
PMID: 9405095

n beta geo, a combined selection and reporter gene for retroviral and transgenic studies.

Blake J, Salinas PC, Hughes SM
Biotechniques. 1997 Oct;23(4):690-5.
PMID: 9343694

Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells.

Wagner U, Brownlees J, Irving NG, Lucas FR, Salinas PC, Miller CC
FEBS Lett. 1997 Jul 14;411(2-3):369-72.
PMID: 9271238

Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.

Ehler E, van Leeuwen F, Collard JG, Salinas PC
Mol Cell Neurosci. 1997 Jan;9(1):1-12.
PMID: 9204476