Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer’s disease, restores synapse integrity and memory in a disease mouse model

Martin-Flores N., Podpolny M., McLeod F., Workman I., Crawford K., Ivanov D., Leonenko G., Escott-Price V., Salinas P.C..
eLife, 2023

S-acylation of the Wnt receptor Frizzled-5 by zDHHC5 controls its cellular localization and synaptogenic activity in the rodent hippocampus

Teo S., Bossio A., Stamatakou E., Pascual-Vargas P., Jones M.E., Schuhmacher L.-N., Salinas P.C..
Developmental Cell, 2023

A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease

Jones M., Buchler J., Dufor T., Palomer E., Teo S., Martin-Flores N., Boroviak K., Metzakopian E., Gibb A. and Salinas P.C..
Science Advances, 2023

Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters 

Palomer E., Martin-Flores N., Jolly S., Pascual-Vargas P., Benvegnu S., Podpolny M., Teo S., Vaher K., Saito T., Saido T., Whiting P. and Salinas P.C.
Molecular Psychiatry, 2022

A role for Frizzled and their post-translational modifications in the mammalian central nervous system.
Pascual-Vargas P. and Salinas P.C.
Front. Cell and Developmental Biology, 2021 [Review]

Wnt-Frizzled signaling regulated activity-mediated synapse formation
Teo S. and Salinas P.C.
Front. Mol Neuroscience, 2021 [Review]

Striatal synapse degeneration and dysfunction are reversed by reactivation of Wnt signaling
Galli, S., Stancheva S.H., Dufor T.,  Gibb A.J. and Salinas P.C.
Front. Synaptic Neurosci., 2021

Wnt signaling through Nitric Oxide synthase promotes the formation of multi-innvervated spines.
McLeod F., Boyle K., Marzo A., Martin-Flores N., Moe T-Z, Palomer E., Gibb A.J. and Salinas P.C.
Front. Synaptic Neurosci., 2020

Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo.
Redlingshöfer L., McLeodF., CamusMC., ChenY., BurdenJJ, PalomerE., BriantK.,Dannhauser PN., SalinasPC. and Brodsky FM.
Proc. Nat. Acad. Sci. USA, 2020

Restoring neuron connections.
Salinas PC.
Science, 2020

Rational design of a conformation-specific antibody for quantification of Aß oligomers.
Aprile, F.A. Sormanni P., Podpolny M., Chhangur S; Needham L-M; Ruggeri F.S. Perni, M.; Limbocker R, Heller., G. T., Sneideris T., Mannini B., Habchi J., Lee S., Salinas P. C., Knowles T. P. J., Dobson  C. M. and Vendruscolo M.
Proc. Nat. Acad. Sci. USA, 2020

Wnt signalling deregulation in the ageing and Alzheimer’s brain.
Palomer E., Buechler J. and Salinas P.C.
Front. Cellular Neuroscience, 2019 [Review]

Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.
Haq N., Schmidt-Hieber C., Sialana F.J. Ciani L., Heller JP, Steward M., Bentley L., Wells S., Rodenburg RJ., Nolan PM, Forsythe E., Wu, MC, Lubec G. Salinas PC, Hausser M., Beales PL. Christou-Savina S.
PLoS Biol., 2019

Single-Cell Quantification of mRNA Expression in The Human Brain.
Jolly S., Lang V., Koelzer2 V.H., Sala Frigerio C., Magno L., Salinas P. C., Whiting P. and Palomer E.
Scientific Reports, 2019

Wnt proteins as modulators of synaptic plasticity.
McLeod F, Salinas PC.
Curr Opin Neurobiol., 2018 [Review]

Deficient Wnt Signaling and Synaptic Vulnerability in Alzheimer’s Disease: Emerging Roles for the LRP6 Receptor.
Buechler J, Salinas PC.
Front Synaptic Neurosci., 2018 [Review]

Wnt7b signalling through Frizzled-7 receptor promotes dendrite development by coactivating CaMKII and JNK.
Ferrari ME, Bernis ME, McLeod F, Podpolny M, Coullery RP, Casadei IM, Salinas PC, Rosso SB.
J Cell Sci., 2018

Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors.
McLeod F, Bossio A, Marzo A, Ciani L, Sibilla S, Hannan S, Wilson GA, Palomer E, Smart TG, Gibb A, Salinas PC.
Cell Reports, 2018

Gender Equality from a European Perspective: Myth and Reality
Salinas P, Bagni C
Neuron, 2017

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
McLeod F, Marzo A, Podpolny M, Galli S, Salinas P
J Vis Exp. 2017

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus.
Marzo A, Galli S, Lopes D, McLeod F, Podpolny M, Segovia-Roldan M, Ciani L, Purro S, Cacucci F, Gibb A, Salinas PC
Curr Biol. 2016

Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes DM, Anane D, McLeod F, Rosso SB, Gibb A, Salinas PC
Nat Commun. 2015

Wnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8.
Stamatakou E, Hoyos-Flight M, Salinas PC
PLoS One. 2015

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice.
Galli S, Lopes DM, Ammari R, Kopra J, Millar SE, Gibb A, Salinas PC
Nat Commun. 2014

Postsynaptic assembly: a role for Wnt signaling.
Stamatakou E, Salinas PC
Dev Neurobiol. 2014

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases.
Purro SA, Galli S, Salinas PC
J Mol Cell Biol. 2014

Wnts in action: from synapse formation to synaptic maintenance.
Dickins EM, Salinas PC
Front Cell Neurosci. 2013

Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation.
Hiester BG, Galati DF, Salinas PC, Jones KR
Mol Cell Neurosci. 2013

Activity-dependent spine morphogenesis: a role for the actin-capping protein Eps8.
Stamatakou E, Marzo A, Gibb A, Salinas PC
J Neurosci. 2013

Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts.
Nethe M, de Kreuk BJ, Tauriello DV, Anthony EC, Snoek B, Stumpel T, Salinas PC, Maurice MM, Geerts D, Deelder AM, Hensbergen PJ, Hordijk PL
J Cell Sci. 2012

The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss.
Purro SA, Dickins EM, Salinas PC
J Neurosci. 2012

Wnt signaling in the vertebrate central nervous system: from axon guidance to synaptic function.
Salinas PC
Cold Spring Harb Perspect Biol. 2012

Dual roles for Wnt signalling during the formation of the vertebrate neuromuscular junction.
Henríquez JP, Salinas PC
Acta Physiol (Oxf). 2012

Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II.
Ciani L, Boyle KA, Dickins E, Sahores M, Anane D, Lopes DM, Gibb AJ, Salinas PC
Proc Natl Acad Sci USA. 2011

Wnt signaling during synaptic development and plasticity.
Budnik V, Salinas PC
Curr Opin Neurobiol. 2011

Activity-mediated synapse formation a role for Wnt-Fz signaling.
Sahores M, Salinas PC
Curr Top Dev Biol. 2011

Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis.
Sahores M, Gibb A, Salinas PC
Development. 2010

Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin.
Henriquez JP, Webb A, Bence M, Bildsoe H, Sahores M, Hughes SM, Salinas PC
Proc Natl Acad Sci USA. 2008

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli.
Purro SA, Ciani L, Hoyos-Flight M, Stamatakou E, Siomou E, Salinas PC
J Neurosci. 2008

From neuronal activity to the actin cytoskeleton: a role for CaMKKs and betaPIX in spine morphogenesis.
Ciani L, Salinas PC
Neuron. 2008

Wnt signaling in neural circuit assembly.
Salinas PC, Zou Y
Annu Rev Neurosci. 2008

c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability.
Ciani L, Salinas PC
BMC Cell Biol. 2007

Modulation of the microtubule cytoskeleton: a role for a divergent canonical Wnt pathway.
Salinas PC
Trends Cell Biol. 2007

Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release.
Ahmad-Annuar A, Ciani L, Simeonidis I, Herreros J, Fredj NB, Rosso SB, Hall A, Brickley S, Salinas PC
J Cell Biol. 2006

Retrograde signalling at the synapse: a role for Wnt proteins.
Salinas PC
Biochem Soc Trans. 2005

Wnt signaling in neural circuit development.
Fradkin LG, Garriga G, Salinas PC, Thomas JB, Yu X, Zou Y
J Neurosci. 2005

Signaling at the vertebrate synapse: new roles for embryonic morphogens?
Salinas PC
J Neurobiol. 2005

WNTs in the vertebrate nervous system: from patterning to neuronal connectivity.
Ciani L, Salinas PC
Nat Rev Neurosci. 2005

Cadherins and catenins in synapse development.
Salinas PC, Price SR
Curr Opin Neurobiol. 2005

Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development.
Rosso SB, Sussman D, Wynshaw-Boris A, Salinas PC
Nat Neurosci. 2005

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules.
Ciani L, Krylova O, Smalley MJ, Dale TC, Salinas PC
J Cell Biol. 2004

The morphogen sonic hedgehog collaborates with netrin-1 to guide axons in the spinal cord.
Salinas PC
Trends Neurosci. 2003

Neurobiology: backchat at the synapse.
Salinas PC
Nature. 2003

Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea.
Dabdoub A, Donohue MJ, Brennan A, Wolf V, Montcouquiol M, Sassoon DA, Hseih JC, Rubin JS, Salinas PC, Kelley MW
Development. 2003

Synaptogenesis: Wnt and TGF-beta take centre stage.
Salinas PC
Curr Biol. 2003

WNT-3, expressed by motoneurons, regulates terminal arborization of neurotrophin-3-responsive spinal sensory neurons.
Krylova O, Herreros J, Cleverley KE, Ehler E, Henriquez JP, Hughes SM, Salinas PC
Neuron. 2002

Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons.
Hall AC, Brennan A, Goold RG, Cleverley K, Lucas FR, Gordon-Weeks PR, Salinas PC
Mol Cell Neurosci. 2002

Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3beta.
Krylova O, Messenger MJ, Salinas PC
J Cell Biol. 2000

Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling.
Hall AC, Lucas FR, Salinas PC
Cell. 2000

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Meijer L, Thunnissen AM, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR
Chem Biol. 2000

Lithium and synaptic plasticity.
Salinas PC, Hall AC
Bipolar Disord. 1999

WNT signaling in the control of hair growth and structure.
Millar SE, Willert K, Salinas PC, Roelink H, Nusse R, Sussman DJ, Barsh GS
Dev Biol. 1999

Control of muscle fibre and motoneuron diversification.
Hughes SM, Salinas PC
Curr Opin Neurobiol. 1999

Wnt factors in axonal remodelling and synaptogenesis.
Salinas PC
Biochem Soc Symp. 1999

Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium.
Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC
J Cell Sci. 1998

WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons.
Lucas FR, Salinas PC
Dev Biol. 1997

n beta geo, a combined selection and reporter gene for retroviral and transgenic studies.
Blake J, Salinas PC, Hughes SM
Biotechniques. 1997

Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells.
Wagner U, Brownlees J, Irving NG, Lucas FR, Salinas PC, Miller CC
FEBS Lett. 1997

Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.
Ehler E, van Leeuwen F, Collard JG, Salinas PC
Mol Cell Neurosci. 1997