Check out our latest paper on the impact of Wnt receptor variant LRP6 Val and the links between synaptic connectivity in ageing and in AD

We are pleased that our paper on the LRP6 Val variant has been published in Science Advances.

We identified that carrying this variant of LRP6 enhances synaptic defects and synapse loss during ageing and increases synapse degeneration in Alzheimer’s disease. These changes in connectivity could result in a detrimental effect on cognitive function in human carriers of the LRP6 variant. The study also identified that the mutant receptor does not initiate Wnt signalling or promote synapse formation in response to Wnt proteins. 

Together, our study provides new insights into potential targets for promoting synapse repair/recovery in Alzheimer’s disease.

Check out our latest paper on epigenetic repression of Wnt receptors in AD

We are excited to share our latest paper published in Molecular Psychiatry on epigenetic repression of Wnt receptors in AD. We define a novel role for nuclear hyperactivated Sirt2 in repressing Fzd1 and Fzd7 expression via H4K16ac deacetylation in AD. We propose Sirt2 as an attractive target to ameliorate AD pathology.

Check out our latest paper on the interplay between Wnt, NOS and LTP

We are excited to share our newest publication on the effects of nitric oxide signalling on the formation of multi-innervated spines. We found that Wnt7a stimulates the formation of MISs via the activation of postsynaptic Dvl1 and retrograde nNOS signalling. The results are published in Frontiers in Synaptic Neuroscience (link).

You can find this and the rest of our publications on our Publications page.