We are excited to share our latest paper published in Molecular Psychiatry on epigenetic repression of Wnt receptors in AD. We define a novel role for nuclear hyperactivated Sirt2 in repressing Fzd1 and Fzd7 expression via H4K16ac deacetylation in AD. We propose Sirt2 as an attractive target to ameliorate AD pathology.
We are excited to share our newest publication on the effects of nitric oxide signalling on the formation of multi-innervated spines. We found that Wnt7a stimulates the formation of MISs via the activation of postsynaptic Dvl1 and retrograde nNOS signalling. The results are published in Frontiers in Synaptic Neuroscience (link).
You can find this and the rest of our publications on our Publications page.